2019 MACH MRFF
Rapid Applied Research Translation
Grants & Fellowships
(Round 2 Stage 1)
2019 Rapid Applied Research Translation Grant Scheme
The aim of this funding scheme is to:
improve patient experience by improving care pathways and service connections;
reduce unwarranted variation in healthcare and patient outcomes;
improve the health of certain at-risk groups in Australia, such as Indigenous Australians; and
support innovative clinical trials.
The MACH offered these two funding opportunities to MACH partner-affiliated researchers (in the form of project grants and research fellowships) to support translational research projects that will produce tangible outcomes of value to the health system within a short period.
This scheme provided distinct opportunities for:
researchers wishing to scale up post proof-of-concept translational research projects across multiple MACH partner hospitals in areas of priority
early career clinician researchers wishing to protect research time to undertake research with a focus on data and health services research, clinical informatics or conducting innovative clinical trials
Dr Andrew Bivard
MACH Partners: Austin Health, Florey Institute of Neuroscience and Mental Health, Melbourne Health, St Vincent’s Hospital Melbourne, University of Melbourne, Western Health
Project title: Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (TASTEa)
Ischemic stroke is a major health burden globally and in Australia. Treatment for ischemic stroke is time critical and is significantly more effective if administered within the first 90 minutes of symptom onset.This clinical trial will identify if early administration of oral thrombolytic agent, tenecteplase prior to hospital can improve outcomes from stroke, and reduce costs compared to standard care of IV alteplase in hospital.
Video coming soon!
A/Prof Luke Burchill
MACH Partners: Austin Health, Melbourne Health, Peter MacCallum Cancer Centre, University of Melbourne
Project title: Closing the gap on Indigenous cardiovascular (CV) health: Improving community outcomes through high impact policy relevant research
CV disease is the largest contributor to the health gap between Indigenous and non-Indigenous Australians. This project will link clinical data collected by Australian general practices, hospitals, and government agencies to determine how variation in CV risk, events and treatment influences Indigenous and non-Indigenous health outcomes.
A/Prof Adam Deane
MACH Partners: Austin Health, Melbourne Health, Northern Health, Peter MacCallum Cancer Centre, St Vincent’s Hospital Melbourne, Royal Women’s Hospital, University of Melbourne, Western Health
Project title: Liberal glUcose Control in critically Ill patient with pre-existing type 2 Diabetes (LUCID): a phase IIB multi-centre parallel group randomised clinical trial
Each year more than 30,000 patients with type 2 diabetes require Intensive Care Unit (ICU) admission. Patient outcomes are poor if blood glucose levels are too high, and so patients are treated with insulin infused directly into the bloodstream. This multicentre randomised clinical trial focuses on improving the management of hyperglycaemia in patients with type II diabetes in critical care, so that interventions occur only a higher blood glucose level. This trial aims to reduce hypoglycaemia and other complications of diabetes and ICU stay in this population.
Prof Gustavo Duque
MACH Partners: Austin Health, University of Melbourne, Western Health
Project title: Integrating Osteoporosis in Primary Care: The Osteoporosis Risk and Management (ORMA) Project
By 2022, it is estimated that 6.2 million Australians older than 50 years of age will have osteoporosis or osteopenia, a rise of 31% from 2012. The ORMA Project will simplify the process for GPs to efficiently and earlier identify patients who may be at risk of osteoporotic fractures. In addition, the program will facilitate efficient management of individuals already diagnosed with the disease.
Prof Harriet Hiscock
MACH Partners: Murdoch Childrens Research Institute, Northern Health, Royal Children's Hospital, University of Melbourne
Project title: Improving the care of children with frequent asthma admissions through partnerships with hospitals, GPs and families
Asthma is the most common chronic childhood illness and accounts for most paediatric hospital admissions. To prevent frequent, costly admissions, we need to understand factors in a child’s care journey associated with re-admissions. This project will follow a group of children who were admitted to one of three hospitals for asthma treatment in 2017 comparing a group of children with at least 1 subsequent asthma re-admission in 2018 to the group of children who are not re-admitted during this time.
A/Prof Craig Nelson
MACH Partners: University of Melbourne, Western Health (including primary care affiliates)
Project title: Future Health Today Project-Co-design of Prototype
Future Health Today is a novel e-technology platform to extract primary care performance data for clinical audit and decision support to facilitate chronic disease prevention, management and quality improvement. The goal of Future Health Today (FHT) is to create a new standard-of-care for patients at risk, or diagnosed with chronic diseases, focused on chronic kidney disease (CKD), type 2 diabetes (T2DM) and cardiovascular disease (CVD).
Dr KARYN ALEXANDER
Future Health Today Project-Co-design of Prototype
Dr KATHERINE CHEN
Improving the care of children with frequent asthma admissions through partnerships with hospitals, GPs, and families
Dr EBRAHIM BANI HASSAN
Integrating Osteoporosis in Primary Care: The Osteoporosis Risk and Management (ORMA) Project
Dr JANE SCHEETZ
Artificial intelligence-assisted opportunistic screening of diabetic retinopathy at endocrinology clinics (linked to a previously MACH funded RART project grant)
Dr MAXIMUS BERGER
Development and validation of a biomarker-guided risk index for the prediction of clinical outcomes in young people at ultra-high risk for psychosis (not linked to a 2019 MACH funded RART project grant)
Learn more about Dr Berger's work