2019 MACH MRFF
Rapid Applied Research Translation
Successful Grants & Fellowships
A/Prof Adam Deane
MACH Partners: Austin Health, Melbourne Health, Northern Health, Peter MacCallum Cancer Centre, St Vincent’s Hospital Melbourne, Royal Women’s Hospital, University of Melbourne, Western Health
Project title: Liberal glUcose Control in critically Ill patient with pre-existing type 2 Diabetes (LUCID): a phase IIB multi-centre parallel group randomised clinical trial
Summary: Each year more than 30,000 patients with type 2 diabetes require Intensive Care Unit (ICU) admission. Patient outcomes are poor if blood glucose levels are too high, and so patients are treated with insulin infused directly into the bloodstream. This multicentre randomised clinical trial focuses on improving the management of hyperglycaemia in patients with type II diabetes in critical care, so that interventions occur only a higher blood glucose level. This trial aims to reduce hypoglycaemia and other complications of diabetes and ICU stay in this population.
About A/Prof Deane's Research Project
What is the problem you're trying to solve?
Each year > 30,000 patients with type 2 diabetes require Intensive Care Unit (ICU) admission. Hyperglycaemia (high blood glucose) is treated identically in all ICU patients regardless of pre-existing diabetes but treatment increases the risk of hypoglycaemia (low blood glucose), which is harmful.
About this research translation project
The Melbourne University Hospitals Group (Melbourne Health, Austin, St Vincent’s, Western and Northern), in collaboration with the Australian New Zealand Intensive Care Society Clinical Trials Group (ANZICS-CTG), will perform a pivotal multicentre randomised clinical trial to compare current treatment to a new approach, where blood glucose is treated only at a higher level in patients with diabetes. This trial will determine whether hypoglycaemia (low blood glucose) and other complications are less, resulting in better patients outcomes with this new approach.
What will be the impact?
This proposed intervention is inexpensive and, if effective, will transform the management of blood glucose in patients with type 2 diabetes who require admission to hospital.
RART 2.2 Expansion Activities
A/Prof Deane received additional funding in our Rapid Applied Research Translation scheme Round 2 Stage 2 for an expansion on his Stage 1 project. Expansion activities include a nested cohort translational study testing the reliability of more accessible use point-of-care and continuous blood glucose monitoring. This will identify clinically important changes in blood sugar, enhancing broader community use of continuous and point-of-care testing.
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For more information on this project, please contact the MACH office:
(03) 8344 9973